Single-cell RNA sequencing of APP KI mice. Mus musculus strain:C57BI/6 and APP KI

Alzheimer's disease (AD) is associated with progressive neuronal degeneration as amyloid-beta or tau proteins accumulate in the brain. Non-neuronal glial cells were recently reported to play an important role in the development of AD. However, the role of oligodendrocytes in AD pathogenesis remains unclear. Here, we elucidate a previously undiscovered disease-associated subpopulation of oligodendrocytes during AD progression in AD mouse models and patients using single-cell RNA sequencing analysis