Chromatin Immunoprecipitation and High-throughput Sequencing from wild type ataxin-1

Significant ChIP-seq peaks corresponding to 1632 unique genes were enriched.Two common motifs enriched in the ataxin-1-binding targets contained the core GGAG and AAAT. The 1573 protein coding genes that bound by ataxin-1 were subjected to Gene Ontology analysis. The most enriched GO terms in molecular function included: ion binding (351 genes), enzyme binding (162 genes), DNA binding (130 genes), signal transducer activity (91 genes), and DNA binding transcription factor activity (84 genes).