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Regulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis [B-cells]

ChEBI2015-05-19 更新2026-07-21 收录

B细胞淋巴瘤机制

pre-mRNA剪接

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-60188 数据链接链接失效反馈

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Regulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis [B-cells]

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创建时间：

2015-05-19

pre-mRNA剪接

核酸二级结构功能

The secondary structure of a pre-mRNA influences a number of processing steps including alternative splicing. Since most splicing regulatory proteins bind to single-stranded RNA, the sequestration of

NIAID Data Ecosystem120

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

B细胞淋巴瘤机制

EZH2靶向治疗

The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B-cells and targeted by somatic mutations in B-cell lymphomas. Here we find that EZH2 deletion or pharmacologic inhibitio

NIAID Data Ecosystem90

A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast

pre-mRNA剪接

酵母遗传学

Mammalian SR proteins are a family of reversibly phosphorylated RNA binding proteins primarily studied for their roles in alternative splicing. While budding yeast lack alternative splicing, they do h

NIAID Data Ecosystem40

Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5. Arabidopsis thaliana

pre-mRNA剪接

拟南芥分子遗传学

In this study, we analyzed the pre-mRNA splicing status in wild-type Col, atprmt5 mutants, and two atprmt5 suppressors (m90 and s215). RNA-seq analyses revealed that m90 and s215 can partially rescue

NIAID Data Ecosystem100

A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer

结直肠癌分子标志物

pre-mRNA剪接

It is widely accepted that most colorectal cancers (CRCs) arise from colorectal adenomas (CRAs), but transcriptomic data characterizing the progression from colorectal normal mucosa to adenoma, and th

NIAID Data Ecosystem60

Regulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis [B-cells]

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