Qingzao Jiufei Decoction improves idiopathic pulmonary fibrosis through TGF-β/Smad signaling regulation

In the study, we hypothesized that QJD could inhibit the development of IPF by modulating the TGF-β/Smad signaling pathway. We used the PFD-induced rat model and the TGF-β1-induced HFL-1 model to verify the positive effect of QJD on IPF.The research results show that,QJD can effectively attenuate IPF-induced lung tissue injury by regulating the TGF-β/Smad signalling pathway, reducing the level of inflammation, and decreasing fibroblast differentiation and collagen fibre production and deposition. This study further confirms the role of the TGF - β/Smad signaling pathway and provides new ideas for the clinical prevention and treatment of IPF.