Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB

Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB Descriptor: (2S,4R)-1-[(2R)-2-[3-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... Authors: Zollman, D, Farnaby, W, Ciulli, A. Deposit date: 2023-10-18 Release date: 2023-12-06 Last modified: 2024-10-02 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Targeting cancer with small-molecule pan-KRAS degraders. Science, 385, 2024化合物4与KRAS (Kirsten大鼠肉瘤病毒癌基因同源物) G12V C118S突变体结合GDP以及pVHL (von Hippel-Lindau蛋白):ElonginC:ElonginB三元复合物的晶体结构 化学标识符：(2S,4R)-1-[(2R)-2-[3-[4-[(3S)-4-[4-[5-[(4S)-2-氨基-3-氰基-4-甲基-6,7-二氢-5H-1-苯并噻吩-4-基]-1,2,4-噁二唑-3-基]嘧啶-2-基]-3-甲基-1,4-二氮杂环庚烷-1-基]丁氧基]-1,2-噁唑-5-基]-3-甲基丁酰基]-N-[[4-(4-甲基-1,3-噻唑-5-基)苯基]甲基]-4-羟基吡咯烷-2-甲酰胺、ElonginB、ElonginC…… 作者：Zollman, D、Farnaby, W、Ciulli, A 存储日期：2023-10-18 发布日期：2023-12-06 最后修改日期：2024-10-02 实验方法：X射线衍射（分辨率2.36 Å） 引用文献：《靶向小分子泛KRAS降解剂治疗癌症》，《科学》，385卷，2024年