Chronic sleep fragmentation exacerbates colitis and alters intestinal barrier and CD4+ T cell function

This study investigates the impact of chronic sleep fragmentation on colitis progression, focusing on its association with impaired intestinal epithelial barrier integrity and altered Th17-associated features of CD4+ T cells. The findings reveal that chronic sleep fragmentation exacerbates colitis by disrupting intestinal barrier function and modulating CD4+ T cell immune responses, providing insights into the link between sleep disturbance and inflammatory bowel disease.