Crystal structure of human SP100 in complex with bromodomain-focused fragment XS039818e 1-(3-Phenyl-1,2,4-oxadiazol-5-yl)methanamine

Crystal structure of human SP100 in complex with bromodomain-focused fragment XS039818e 1-(3-Phenyl-1,2,4-oxadiazol-5-yl)methanamine Descriptor: (3-phenyl-1,2,4-oxadiazol-5-yl)methanamine, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... Authors: Talon, R.P.H, Krojer, T, Tallant, C, Nunez-Alonso, G, Fairhead, M, Szykowska, A, Collins, P, Pearce, N.M, Ng, J, MacLean, E, Wright, N, Douangamath, A, Brandao-Neto, J, Burgess-Brown, N, Huber, K, Knapp, S, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F. Deposit date: 2018-03-29 Release date: 2018-04-11 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.765 Å) Cite: Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces Biorxiv, 2018

人源SP100与溴结构域（bromodomain）靶向片段XS039818e（化学名称：1-(3-苯基-1,2,4-恶二唑-5-基)甲胺）的复合物晶体结构。描述符：(3-苯基-1,2,4-恶二唑-5-基)甲胺、1,2-乙二醇、2-(N-吗啉代)乙磺酸等。作者：Talon, R.P.H、Krojer, T、Tallant, C、Nunez-Alonso, G、Fairhead, M、Szykowska, A、Collins, P、Pearce, N.M、Ng, J、MacLean, E、Wright, N、Douangamath, A、Brandao-Neto, J、Burgess-Brown, N、Huber, K、Knapp, S、Brennan, P.E、Arrowsmith, C.H、Edwards, A.M、Bountra, C、von Delft, F。存入日期：2018年3月29日；发布日期：2018年4月11日；最后修改日期：2024年5月1日；实验方法：X射线衍射（分辨率1.765埃）；引用文献：《在结构域-结构域界面识别表观遗传蛋白的小分子结合位点》，BioRxiv，2018年。