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Gene expression profiles of nurse-like cells (NLCs) generated in vitro from chronic lymphocytic leukemia in presence of lenalidomide

ChEBI2014-11-24 更新2026-07-21 收录

慢性淋巴细胞白血病微环境

肿瘤免疫药物响应

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-57861 数据链接链接失效反馈

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资源简介：

Gene expression profiles of nurse-like cells (NLCs) generated in vitro from chronic lymphocytic leukemia in presence of lenalidomide

应用场景：

创建时间：

2014-11-24

慢性淋巴细胞白血病微环境

Notch-Wnt信号调控

We used microarrays to investigate differential gene expression in mouse bone marrow derived mesenchymal stromal cells, proficient or deficient for Notch2, cultured for 5 days in the presence or absen

NIAID Data Ecosystem80

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation

慢性淋巴细胞白血病微环境

CXCR5信号通路

In human chronic lymphocytic leukemia (CLL) pathogenesis B cell antigen receptor signaling seems important for leukemia B cell ontogeny, whereas the microenvironment influences B cell activation, tumo

NIAID Data Ecosystem60

Genome-wide analysis of impact of B cells from the peripheral blood of chronic lymphocytic leukemia (CLL) patients versus B cells from healthy donors on CD14+ PBMCs from healthy donors

慢性淋巴细胞白血病微环境

细胞转录组分析

CD14+ cells in the PBMCs of CLL patients are converted into NLCs. CD14+ PBMCs from healthy donors when cultured with CLL cells give rise to differentiated cells called CD14CLL-cells, which are immunop

NIAID Data Ecosystem40

Interaction between endothelium and chronic lymphocytic leukemia B-cells rescues from apoptosis and modulates gene expression profile of leukemic cells

慢性淋巴细胞白血病微环境

肿瘤内皮细胞

Chronic lymphocytic leukemic B cells (CLL) reside in close contact with activated endothelial cells (EC) in infiltrated tissues. Here, we investigated the interactions between EC and CLL cells, highli

NIAID Data Ecosystem70

Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia.

慢性淋巴细胞白血病微环境

巨噬细胞介导的生存信号

Protective interactions with bystander cells in micro-environmental niches such as lymph nodes (LNs) contribute to survival and therapy resistance of chronic lymphocytic leukemia (CLL) cells. This is

NIAID Data Ecosystem50

Gene expression profiles of nurse-like cells (NLCs) generated in vitro from chronic lymphocytic leukemia in presence of lenalidomide

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