pgc-mdd

# PGC Major Depressive Disorder — GWAS Summary Statistics [](https://creativecommons.org/licenses/by/4.0/) ## Dataset Description Genome-wide association study (GWAS) summary statistics for **Major Depressive Disorder** phenotypes from the [Psychiatric Genomics Consortium (PGC)](https://pgc.unc.edu/). Each publication is available as a separate subset (config) and can be loaded independently. ## Usage ```python from datasets import load_dataset # Load a specific GWAS ds = load_dataset("OpenMed/pgc-mdd", "AntiDepResponse2021") print(ds) ``` ### List all available subsets ```python from datasets import get_dataset_config_names print(get_dataset_config_names("OpenMed/pgc-mdd")) ``` ## Subsets | Config | Phenotype | Journal | Year | PubMed | |--------|-----------|---------|------|--------| | `AntiDepResponse2021` | Antidepressant Response | Biol Psychiatry: Global Open Science | 2021 | Pending | | `mdd2013` | Major Depression | Molecular Psychiatry | 2013 | [22472876](https://pubmed.ncbi.nlm.nih.gov/22472876/) | | `mdd2018` | Major Depression | Nature Genetics | 2018 | [29700475](https://pubmed.ncbi.nlm.nih.gov/29700475/) | | `mdd2018_noUKBB` | Major Depression (no UK Biobank) | Nature Genetics | 2018 | [29700475](https://pubmed.ncbi.nlm.nih.gov/29700475/) | | `mdd2021asi` | Major Depression (East Asian) | JAMA Psychiatry | 2021 | [34586374](https://pubmed.ncbi.nlm.nih.gov/34586374/) | | `mdd2023diverse` | Major Depression (Multi-Ancestry) | Nature Genetics | 2023 | [38177345](https://pubmed.ncbi.nlm.nih.gov/38177345/) | | `mdd2025` | Major Depression | Cell | 2025 | [39814019](https://pubmed.ncbi.nlm.nih.gov/39814019/) | | `ppd2023` | Peripartum Depression | American Journal of Psychiatry | 2023 | [37849304](https://pubmed.ncbi.nlm.nih.gov/37849304/) | ## Data Format All data is stored as **Apache Parquet** shards (10,000 rows each). Common columns: | Column | Description | |--------|-------------| | `SNP` / `ID` | SNP rsID or variant identifier | | `CHR` | Chromosome | | `BP` / `POS` | Base-pair position (typically GRCh37/hg19) | | `A1` | Effect allele | | `A2` | Non-effect allele | | `OR` / `BETA` | Odds ratio or effect size | | `SE` | Standard error | | `P` | P-value | | `_source_file` | Original source filename | > Column names vary between publications. Check each subset's schema. ## Citation Please cite the original publication (see PubMed links above) and acknowledge the PGC: > Data were obtained from the Psychiatric Genomics Consortium — https://pgc.unc.edu/ ## Terms of Use Released under **[CC BY 4.0](https://creativecommons.org/licenses/by/4.0/)** / **[CC0 1.0](https://creativecommons.org/publicdomain/zero/1.0/)**. - Cite the original publication(s) - Do not attempt to re-identify individual participants - Comply with the PGC [data use policies](https://pgc.unc.edu/for-researchers/data-access/) ## Source - [Psychiatric Genomics Consortium (PGC)](https://pgc.unc.edu/) - [PGC Downloads](https://pgc.unc.edu/for-researchers/download-results/) --- *Last updated: April 2026*