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Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)

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Figshare2016-01-18 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Synthetic_RNA_Silencing_of_Actinorhodin_Biosynthesis_in_Streptomyces_coelicolor_A3_2_/733700
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We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and metabolic engineering studies in Streptomyces.
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2016-01-18
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