Disrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease
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https://www.ncbi.nlm.nih.gov/sra/SRP045727
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资源简介：
Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. Overall design: We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification that inhibits AR transactivation function.
创建时间：
2019-09-23
