Crystal structure of the complex between PPARgamma LBD and the ligand LJ570: structure obtained from crystals of the apo-form soaked for 15 days.

Crystal structure of the complex between PPARgamma LBD and the ligand LJ570: structure obtained from crystals of the apo-form soaked for 15 days. Descriptor: (2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid, Peroxisome proliferator-activated receptor gamma Authors: Pochetti, G, Montanari, M. Deposit date: 2017-11-24 Release date: 2018-01-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Identification of the First PPAR alpha / gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation. J.Med.Chem., 61, 2018

过氧化物酶体增殖物激活受体γ配体结合域（PPARgamma LBD）与配体LJ570形成复合物的晶体结构：该结构来源于经15天浸泡的无配体形式（apo-form）晶体。描述信息：(2S)-3-(联苯-4-基)-2-(联苯-4-基氧基)丙酸、过氧化物酶体增殖物激活受体γ。作者：Pochetti, G、Montanari, M。提交日期：2017-11-24。发布日期：2018-01-10。最后修改日期：2024-02-07。结构解析方法：X射线衍射法（X-RAY DIFFRACTION），分辨率2.1 Å。引用文献：《首个可结合PPARγ经典与可变结合位点并抑制其Cdk5介导磷酸化的PPARα/γ双重激动剂的鉴定》，《药物化学杂志》（J.Med.Chem.），2018年，第61卷。