Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake

The primary function of the small intestine (SI) is to absorb nutrients to maintain whole body energy homeostasis. Enterocytes are the major epithelial cell type facilitating nutrient sensing and uptake. However, the molecular regulators governing enterocytes have remained undefined. In this project, we studied the role of the transcription factor c-Maf for the differentiation and function of SI enterocytes.