FoxO are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Mus musculus

To investigate the role of FoxO transcription factors as mediators of hematopoietic stem cell resistance to oxidative stress. Keywords: Hematopoietic stem cells, myeloid progenitors, oxidative stress, ROS, Affymetrix Mouse Genome 430 2.0 Overall design: Study the effect of the deficiency of FoxO1, FoxO3, and FoxO4 in murine bone marrow hematopoietic stem cells and myeloid progenitors on expression of genes involved in reactive oxygen species (ROS) metabolism.