Effect of vendor difference in oral and gut microbiomes on oral cancer development in mice

The role of microbiota as a double-edged sword in cancer is increasingly recognized. Our previous in vitro studies demonstrate that Streptococcus mitis possesses anticancer properties against oral cancer cell lines. In this study, we aimed to validate these findings in the 4-NQO (4-nitroquinoline 1-oxide) induced oral cancer mouse model. Given that mice from different vendors harbor distinct microbiomes, which can influence disease and experimental outcomes, we also assessed whether vendor-specific oral and/or gut microbiome differences affect susceptibility to oral carcinogenesis as well as the response to S. mitis intervention.