Neutrophils, GPI-negative population and outcome of 30 AA patients followed since diagnosis and treated with IST as first line therapy.

hATG = horse ATG; rATG = rabbit ATG; CSA = cyclosporin. In patients treated with hATG evaluation at 180 days showed 2 complete responders (CR, 14%), 7 partial-responders (PR, 50%) and 5 non-responders (NR, 36%), whereas in patients treated with rATG evaluation at 180 days showed 1 CR (7%), 2 PR (14%), 11 NR (79%) (2-tailed Fisher test p = 0.0542).
Among the 11 patients GPI negative at diagnosis, CR and PR were respectively 1 (9%) and 4 (36%), whereas NR were 6 (55%). Among the 19 patients GPI positive at diagnosis CR and PR were respectively 3 (16%) and 5 (26%), whereas NR were 11 (58%) (2-tailed Fisher test p = 1). In all the 4 GPI-negative patients who were treated with rATG the clone persisted at day +180, whereas it disappeared in 4/7 patients receiving hATG up-front.