Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs [BulkRNA]
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP488223
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资源简介：
Through a multi-omics approach, we discovered that metformin acts by enhancing the methylation potential in Dnmt3aR878H/+ cells and reversing their aberrant DNA CpG methylation and histone H3K27 trimethylation (H3K27me3) profiles. Overall design: To investigate the mechanism of action, we performed transcriptome profiling of Dnmt3a+/+ and mutant Dnmt3aR878H/+ HSPCs treated with or without metformin for 1 month.
创建时间：
2025-05-10
