Pharmacotherapy in Autism Spectrum Disorder

We present psychotropic medication use in children with ASD from low-income families who lacked specialized behavioral therapy. Most children received psychopharmacological intervention. One-third underwent a polypharmacy regimen. Polytherapy regimen was associate with ASD level 3 and epilepsy. Age and epilepsy increased the odds of a polytherapy regimen. The most used classes were antipsychotics, followed by antiseizure and antidepressants. The most used psychotropic medications were risperidone and periciazine. The combined use of valproic acid and risperidone was the most frequent combination本研究报道了缺乏专业行为治疗的低收入家庭孤独症谱系障碍（Autism Spectrum Disorder, ASD）儿童的精神药物使用现状。该群体中多数儿童接受了精神药物干预，其中三分之一采用了多重用药方案。多重用药方案与孤独症谱系障碍3级及癫痫存在关联；年龄与癫痫均会提升多重用药方案的发生比值比。本研究中最常用的精神药物类别依次为抗精神病药物，其次为抗癫痫药物与抗抑郁药物；最常使用的精神药物为利培酮与哌氰嗪，而丙戊酸联合利培酮则是最常见的联合用药方案。