Recruitment of HDAC1 by p107 (RBL1)

p107 (RBL1) in complex with E2F4 and DP1 or DP2 recruits histone deacetylase HDAC1 (possibly in complex with other chromatin modification proteins) through LXCXE-like motif, shared by pocket proteins, to repress transcription of E2F target genes in early G1.

p107（RBL1）与E2F4及DP1或DP2形成复合物，通过LXCXE样基序（该基序由口袋蛋白共享），招募组蛋白脱乙酰化酶HDAC1（可能与其他染色质修饰蛋白形成复合物）以抑制早期G1期E2F靶基因的转录。