Perfusion index in newborns during critical congenital heart disease screening at 24 hours in healthy newborns: retrospective observational study from the United States

Objective: To describe the distribution of Perfusion Index (PI) in asymptomatic newborns at 24 hours of life when screening for Critical Congenital Heart Disease (CCHD) using an automated data selection method. Design: This is a retrospective observational study. Setting: Newborn nursery in a California public hospital with 3500 to 4000 deliveries annually. Methods: We developed an automated program to select the PI values from CCHD screens. Included were term and late preterm infants who were screened for CCHD from November 2013 to January 2014 and from May 2015 to July 2015. PI measurements were downloaded every 2 seconds from the pulse oximeter and median PI were calculated for each oxygen saturation screen in our cohort. Results: We included data from 2768 oxygen saturation screens. Each screen had a median of 29 data points (interquartile range 17 to 49). The median PI in our study cohort was 1.8 (95% confidence interval 1.8 to 1.9) with interquartile range 1.2 to 2.7. The medi...研究目的：本研究旨在采用自动化数据筛选方法，描述出生24小时的无症状新生儿在接受重症先天性心脏病（Critical Congenital Heart Disease, CCHD）筛查时的灌注指数（Perfusion Index, PI）分布情况。 研究设计：本研究为回顾性观察性研究。 研究场景：加利福尼亚州一所公立医疗机构的新生儿病房，年分娩量为3500至4000例。 研究方法：我们开发了一套自动化程序，用于提取重症先天性心脏病筛查中的灌注指数数据。本队列纳入2013年11月至2014年1月、2015年5月至2015年7月期间接受重症先天性心脏病筛查的足月儿及晚期早产儿。研究每2秒从脉搏血氧仪（pulse oximeter）下载一次灌注指数测量值，并为本队列中每一次血氧饱和度筛查计算灌注指数中位数。 研究结果：本研究共纳入2768次血氧饱和度筛查数据。每次筛查的中位数数据点数量为29个（四分位距（interquartile range）17~49）。本研究队列的灌注指数中位数为1.8（95%置信区间（confidence interval）1.8~1.9），四分位距为1.2~2.7。