Expression data from type 2 diabetes mellitus adipose-derived stem cells cultured with basic fibroblast growth factor

Diabetes affects ASCs characteristics such as: proliferation, differentiation and angiogenic capacity. MicroRNAs are able to target genes involved in vascular remodeling and promote or inhibit structural changes in the vessel wall. Adipose tissue-derived stem cells (ASCs) have the capacity to contribute to vascular remodeling. We used microarrays to detail the global miRNA expression profile underlying cell differentiation and identified distinct classes of up-regulated and down-regulated genes during this process. Human ASCs from white AT were obtained by surgical procedures from type 2 diabetes mellitus patients. ASCs from fat depots type 2 diabetes mellitus subjects were induced to differentiate into ECs. The expression of 2025 pre-miRNAs and 2578 mature miRNAs was assessed.