Comparison of network and phylogenetic tree distances between 419 kinase domains.

Pearson's correlations (R) and associated Z-scores (Z) and P-values (P) describing the similarity between the relative pairwise distances between 419 human kinase domain sequences in common as assessed by (A) all shortest paths between ?log10(BLAST E-values), (B) the shortest paths between sequences as displayed by a two-dimensional graph layout algorithm, and (C) the shortest paths between sequences in the phylogenetic tree published in Manning et al. 2002[18]. The pairwise BLAST E-values and the graph layout algorithm correspond to a network thresholded at an E-value of 1��10?25.