Synovial fibroblast positional identity controlled by inductive Notch signaling underlies pathologic damage in inflammatory arthritis
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE145286
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资源简介：
Effect of Notch3 perturbation on healthy and arthritic mouse synovium. Mouse synovial tissues were dissected from knee joints. Pooled synovial tissue from 10 mice from each treatment group were enzymatically dissociated. Synovial cells were stained with LIVE/DEAD stain (ThermoFisher) and live synovial cells were isolated by flow cytometric sorting. 7,000 - 10,000 live synovial cells were then used for droplet-based single cell RNAseq (10X Genomics). Mice were either healthy or arthritic (serum transfer from K/BxN). Treatment conditions: isotype control vs anti-Notch3 mAB, wild type vs Notch3-/- knock out.
创建时间：
2021-02-01
