Demir1994_SinoatrialNode

This a model from the article:
A mathematical model of a rabbit sinoatrial node cell.

Demir SS, Clark JW, Murphey CR, Giles WR. Am J Physiol
1994 Mar;266(3 Pt 1):C832-52 8166247
,
Abstract:

A mathematical model for the electrophysiological responses of a rabbit
sinoatrial node cell that is based on whole cell recordings from enzymatically
isolated single pacemaker cells at 37 degrees C has been developed. The ion
channels, Na(+)-K+ and Ca2+ pumps, and Na(+)-Ca2+ exchanger in the surface
membrane (sarcolemma) are described using equations for these known currents in
mammalian pacemaker cells. The extracellular environment is treated as a
diffusion-limited space, and the myoplasm contains Ca(2+)-binding proteins
(calmodulin and troponin). Original features of this model include 1) new
equations for the hyperpolarization-activated inward current, 2) assessment of
the role of the transient-type Ca2+ current during pacemaker depolarization, 3)
inclusion of an Na+ current based on recent experimental data, and 4)
demonstration of the possible influence of pump and exchanger currents and
background currents on the pacemaker rate. This model provides acceptable fits
to voltage-clamp and action potential data and can be used to seek biophysically
based explanations of the electrophysiological activity in the rabbit sinoatrial
node cell.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Demir SS, Clark JW, Murphey CR, Giles WR. (1994) - version01

The original CellML model was created by:
Lloyd, Catherine, May

[e-mail]
The University of Auckland
The Bioengineering Institute
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