Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with 5-((3-(4H-1,2,4-triazol-4-yl)phenyl)amino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with 5-((3-(4H-1,2,4-triazol-4-yl)phenyl)amino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile Descriptor: 1,2-ETHANEDIOL, 7-(cyclopropylamino)-5-[[3-(1,2,4-triazol-4-yl)phenyl]amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Casein kinase II subunit alpha, ... Authors: Kraemer, A, Ong, H.W, Yang, X, Bown, J.W, Chang, E, Willson, T, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2023-05-09 Release date: 2023-05-17 Last modified: 2024-08-07 Method: X-RAY DIFFRACTION (2.4 Å) Cite: More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting beta-Coronavirus Replication. J.Med.Chem., 67, 2024

人类酪蛋白激酶II α亚基（Casein Kinase II subunit alpha, CK2a1）与5-((3-(4H-1,2,4-三唑-4-基)苯基)氨基)-7-(环丙基氨基)吡唑并[1,5-a]嘧啶-3-甲腈复合物的晶体结构。描述符：1,2-乙二醇、7-(环丙基氨基)-5-[[3-(1,2,4-三唑-4-基)苯基]氨基]吡唑并[1,5-a]嘧啶-3-甲腈、酪蛋白激酶II α亚基……。作者：Kraemer, A、Ong, H.W、Yang, X、Bown, J.W、Chang, E、Willson, T、Knapp, S、结构基因组学联合体（Structural Genomics Consortium, SGC）。沉积日期：2023-05-09；发布日期：2023-05-17；最后修改日期：2024-08-07。实验方法：X射线衍射（分辨率2.4 Å）。引用文献：《超越酰胺生物电子等排体：发现含1,2,4-三唑的吡唑并[1,5-a]嘧啶类宿主CSNK2抑制剂用于对抗β冠状病毒复制》，《药物化学杂志（Journal of Medicinal Chemistry）》，2024年，第67卷。