Estrogen Receptor Alpha Ligand Binding Domain in Complex with (1'-(4-(2-(1-ethylpyrrolidin-3-yl)ethoxy)phenyl)-6'-hydroxy-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone

Estrogen Receptor Alpha Ligand Binding Domain in Complex with (1'-(4-(2-(1-ethylpyrrolidin-3-yl)ethoxy)phenyl)-6'-hydroxy-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone Descriptor: Estrogen receptor, [(1'R)-1'-(4-{[(3R)-1-ethylpyrrolidin-3-yl]methoxy}phenyl)-6'-hydroxy-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl](phenyl)methanone Authors: Hancock, G.R, Young, K.S, Hosfield, D.J, Joiner, C, Sullivan, E.A, Yildz, Y, Laine, M, Greene, G.L, Fanning, S.W. Deposit date: 2022-07-27 Release date: 2022-11-09 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells. NPJ Breast Cancer, 8, 2022

雌激素受体α（Estrogen Receptor Alpha）配体结合结构域与(1'-(4-(2-(1-乙基吡咯烷-3-基)乙氧基)苯基)-6'-羟基-1',4'-二氢-2'H-螺[环丙烷-1,3'-异喹啉]-2'-基)(苯基)甲酮的复合物
描述内容：雌激素受体，[(1'R)-1'-(4-{[(3R)-1-乙基吡咯烷-3-基]甲氧基}苯基)-6'-羟基-1',4'-二氢-2'H-螺[环丙烷-1,3'-异喹啉]-2'-基](苯基)甲酮
作者：Hancock, G.R.、Young, K.S.、Hosfield, D.J.、Joiner, C.、Sullivan, E.A.、Yildz, Y.、Laine, M.、Greene, G.L.、Fanning, S.W.
提交日期：2022-07-27
发布日期：2022-11-09
最后修改日期：2023-10-25
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.7埃（Å）
引用文献：《基于异喹啉的非传统选择性雌激素受体调节剂（Selective Estrogen Receptor Modulators，简称SERMs）在ER阳性（ER+）乳腺癌细胞中引发类似氟维司群的转录程序》，《NPJ乳腺癌（NPJ Breast Cancer）》，第8卷，2022年