Comparing gene expression profiles of HCmel3 mouse melanomas treated (early-during-treatment, EDT d12-d20 after ACT onset) with gp100-specific adoptive pmel-1 T cell transfer (ACT) versus non-treated control HCmel3 melanomas. Mus musculus

This data was also integrated with gene expression profiles from late relapse tumors (GSE40213) to compare changes from early-during-treatment to late relapse versus non-treated. These re-analyzed samples are available in this series. In EDT samples we observed typical changes consistent with an effective anti-tumor T cell response including CD8 T cell infiltration, interferon pathway activation and downregulation of proliferation associated gene sets. Overall design: Total RNA was isolated from excised and liquid nitrogen frozen tumors and global gene expression was performed using the Illumina Mouse WG6 v2.0 platform.