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Common PIK3CA mutants and a novel 3’UTR mutation are associated with increased sensitivity to saracatinib

ChEBI2012-02-24 更新2026-07-21 收录

肿瘤靶向治疗

基因突变与药物敏感性

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-36006 数据链接链接失效反馈

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Common PIK3CA mutants and a novel 3’UTR mutation are associated with increased sensitivity to saracatinib

应用场景：

创建时间：

2012-02-24

肿瘤靶向治疗

药物耐药机制

Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c

NIAID Data Ecosystem90

Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation

PARP抑制剂机制

肿瘤靶向治疗

PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytoto

NIAID Data Ecosystem70

Autonomous rhythmic activity in glioma networks drives brain tumor growth

胶质母细胞瘤机制

肿瘤靶向治疗

Glioblastoma cell networks harbor a plastic population of highly active glioblastoma cells that display rhythmic Ca2+ oscillations and are particularly connected to others. Targeting the autonomous rh

NIAID Data Ecosystem40

肿瘤靶分子临床研究信息数据集

肿瘤靶向治疗

临床研究

聚焦肿瘤靶分子临床研究全流程，整合靶点发现、临床试验设计、疗效数据、安全性评估等核心信息。数据经标准化清洗与专业校验，关联靶点分子结构、作用机制及临床结果，支持科研机构靶点验证、药企药物研发、临床机构方案优化，为靶分子临床转化提供高质量、可溯源的数据支撑。

江苏数据交易所80

Regulation of gene expressions in vivo by anti-VEGF and anti-Notch therapy [HG-U133_Plus_2]

肿瘤靶向治疗

基因表达谱分析

U87-EV human glioblastoma xenograft tumours is therapeutically treated by bevacizumab, a humanized anti-human VEGF mAb, or dibenzazepine (DBZ), when tumour is established in BALB/c SCID mice. At the e

NIAID Data Ecosystem50

Common PIK3CA mutants and a novel 3’UTR mutation are associated with increased sensitivity to saracatinib

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