Microbiome analysis of Korean nasopharyngeal lymphoid tissue

This study aims to characterize the microbial communities present in the human nasopharyngeal lymphoid tissue using full-length 16S rRNA amplicon sequencing. The sequencing was performed to investigate the composition and diversity of the nasopharyngeal microbiome in the context of different COVID-19 immunity statuses. The study groups include: SARS-CoV-2 vaccinated healthy donors without infection history (HV), unvaccinated donors with SARS-CoV-2 infection history (CV), vaccinated donors who experienced breakthrough infection (BR), and donors with hybrid immunity who were infected before vaccination (HD).