LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria Descriptor: (2S,4S)-N-[(3R,5R)-1-cyclopropylcarbonyl-5-[[[2-methyl-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenyl]carbonylamino]methyl]pyrrolidin-3-yl]-4-fluoranyl-pyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION Authors: Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. Deposit date: 2021-08-25 Release date: 2022-09-07 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.1 Å) Cite: LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published

以氟脯氨酸作为新型锌结合基团的LpxC抑制剂：可作为一类新型抗多重耐药革兰氏阴性菌抗生素
描述符：(2S,4S)-N-[(3R,5R)-1-环丙基羰基-5-[[[2-甲基-4-[2-[4-(吗啉-4-基甲基)苯基]乙炔基]苯基]羰基氨基]甲基]吡咯烷-3-基]-4-氟吡咯烷-2-甲酰胺；UDP-3-O-酰基-N-乙酰葡糖胺脱乙酰酶（UDP-3-O-acyl-N-acetylglucosamine deacetylase）；锌离子（ZINC ION）
作者：Ryan, M.D.、Pallin, T.D.、Lamers, M.B.A.C.、Leonard, P.M.
存入日期：2021-08-25
发布日期：2022-09-07
最后修改日期：2024-01-31
测试方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.1埃）
引用文献：《以氟脯氨酸作为新型锌结合基团的LpxC抑制剂：可作为一类新型抗多重耐药革兰氏阴性菌抗生素》（待发表）