Investigation of the changes induce by inhibiting mitochondrial respiration on DNA methylation and hydroxymethylation in periosteal cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE198222
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The metabolic changes induced by blocking mitochondrial respiration result in a decrease of 5hmC levels. This experiment aims to further investigate the changes in DNA demethylation induced by Antimycin A treatment using both regular bisulfite- and oxidative bisulfite-chip sequencing. Periosteal cells isolated from 3 pools of mice were treated either by Antimycin A (AMA) or vehicle as control. 10 days after isolation, the effect on DNA methylation and hydroxymethylation was investigated.
创建时间:
2022-08-27



