Fc Heterodimer Design 5.1 T366V + Y407F

Fc Heterodimer Design 5.1 T366V + Y407F Descriptor: Fc-III peptide, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Atwell, S, Leaver-Fay, A, Froning, K.J, Aldaz, H, Pustilnik, A, Lu, F, Huang, F, Yuan, R, Dhanani, S.H, Chamberlain, A.K, Fitchett, J.R, Gutierrez, B, Hendle, J, Demarest, S.J, Kuhlman, B. Deposit date: 2015-09-02 Release date: 2016-03-30 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Computationally Designed Bispecific Antibodies using Negative State Repertoires. Structure, 24, 2016

Fc异二聚体设计5.1 T366V + Y407F 描述符：Fc-III肽（Fc-III peptide）、免疫球蛋白γ-1链C区（Ig gamma-1 chain C region）、β-D-吡喃半乳糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→6)-[α-D-吡喃甘露糖-(1→3)]β-D-吡喃甘露糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-吡喃岩藻糖-(1→6)]2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖；作者：Atwell S、Leaver-Fay A、Froning K.J、Aldaz H、Pustilnik A、Lu F、Huang F、Yuan R、Dhanani S.H、Chamberlain A.K、Fitchett J.R、Gutierrez B、Hendle J、Demarest S.J、Kuhlman B；提交日期：2015-09-02；发布日期：2016-03-30；最后修改日期：2024-10-16；测试方法：X射线衍射（分辨率2.3 Å）；引用文献：《使用负态库计算设计双特异性抗体》，《Structure》，第24卷，2016年