Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with a nanobody (Nb58)

Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with a nanobody (Nb58) Descriptor: Isoform B of Potassium channel subfamily K member 10, Nanobody 58, POTASSIUM ION Authors: Rodstrom, K.E.J, Pike, A.C.W, Baronina, A, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) Deposit date: 2023-10-26 Release date: 2024-05-29 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.588 Å) Cite: Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024

人类双孔结构域钾离子通道TREK-2（K2P10.1）与纳米抗体（nanobody, Nb58）结合的晶体结构。描述项：钾离子通道K亚家族成员10的B亚型、纳米抗体58、钾离子。作者：Rodstrom, K.E.J、Pike, A.C.W、Baronina, A、Ang, J、Bushell, S.R、Chalk, R、Mukhopadhyay, S.M.M、Pardon, E、Arrowsmith, C.H、Edwards, A.M、Bountra, C、Burgess-Brown, N.A、Tucker, S.J、Steyaert, J、Carpenter, E.P，结构基因组学联盟（Structural Genomics Consortium, SGC）。存档日期：2023-10-26；发布日期：2024-05-29；最后修改日期：2024-11-06。研究方法：X射线衍射（X-RAY DIFFRACTION），分辨率3.588埃（Å）。引用文献：《利用纳米抗体对TREK-2活性进行胞外调控可阐明K2P通道的调控机制》，《自然-通讯》（Nat Commun），2024年，第15卷。