Single nuclei transcriptomic profiling of human astrocytes and oligodendrocytes in Alzheimer’s disease II. Single nuclei transcriptomic profiling of human astrocytes and oligodendrocytes in Alzheimer’s disease II

Single nuclei RNA sequencing (snRNA-seq) dataset characterizing nuclei from a putative astrocyte enrichment method: SOX9-positive sorting. Overall design: As a pilot to test this putative astrocyte enrichment method, nuclei were isolated from human post-mortem prefrontal cortex from 5 donors (NS patients = 3, AD patients = 2). Sorted SOX9-positive and SOX-negative were prepared for snRNA-seq using Single Cell 3’ Gene Expression kit v3 (10x Chromium). Generated snRNA-seq libraries were sequenced using an Illumina NovaSeq 6000.