five

Deep mutational scanning of SARS-related coronavirus RBDs using yeast display of barcoded libraries

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA962117
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We performed deep mutational scanning and related experiments on a collection of wildtype and mutated receptor-binding domains (RBDs) from a panel of SARS-related coronavirus isolates, including a pan-sarbecovirus survey library and complete deep mutational scans in RshSTT182, SARS-CoV-1, RsYN04, PRD-0038, and RmYN02. We used these libraries to measure phenotypes such as binding to ACE2 orthologs or antibodies.
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2023-04-26
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