Maternal diet and gut microbiome composition modulate early life immune development

Early life is a critical period for the development of the newborn intestine, which undergoes microbiome colonization concomitant with the maturation of the mucus barrier and the immune system. As dietary fiber exerts a powerful impact on both the microbiome and immune function in adult mice, we sought to understand its role in early life by breeding mice colonized with a 13 or 14-member synthetic microbiome community (13SM or 14SM), fed a fiber-rich (FR) or fiber-free (FF) diet. We then analysed the proportion of innate and adaptive immune cells at 15 days of age, during weaning.
Conclusion:
Maternal fiber deprivation and microbiome significantly impacted the proportions of innate and adaptive immune cell subsets, especially skewing on the type 2 versus type 3 proportions in the presence or absence of Akkermansia (i.e. 13SM or 14SM).
Notes:
NA FMO, compensation samples