Protein-protein contact probability map for conf1 (upper half) and conf2 (lower half) during different stages of the simulations: (a) 1–2 µs, (b) 9–10 µs, (c) 19–20 µs, and (d) 24–25 µs.

The color scale on the right refers to the P value (the same scale is in Figures 4b and S4). All P values were calculated from the number of residue-residue contacts normalized as indicated in eqn2. The critical contact regions are highlighted with circles and labeled by Ln: linker, An: anchor, L: loop, SI: switch I, SII: switch II, α: α helix, β: β-strand.