Supplementary Material for: Protective Effects of ACEI/ARB on Left Ventricular Function in Anthracycline-Induced Chronic Cardiotoxicity: A Meta-Analysis of Randomized Controlled Trials

<b><i>Purpose:</i></b> Cardiotoxicity is an important side effect of anthracycline. Cardioprotective drugs for anthracycline remain inconclusive. We attempted to determine the role of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-receptor blockers (ARB) in the prevention of anthracycline-induced cardiotoxicity. <b><i>Hypothesis:</i></b> Prophylactic use of ACEI/ARB reduces the clinical or subclinical cardiotoxicity of anthracycline. <b><i>Methods:</i></b> Randomized controlled trials (RCTs) of ACEI/ARB in the prevention of anthracycline-induced cardiotoxicity were obtained by searching Pubmed, Embase, Web of Science, and Cochrane databases. 7 studies were finally included. A meta-analysis was performed on the 7 studies. The end points were changes in left ventricle ejection fraction (LVEF), early and late diastolic peak velocity ratio (<i>E</i>/<i>A</i>), and occurrence of hypotensive events. <b><i>Results:</i></b> Prophylactic use of ACEI/ARB has potential benefits for anthracycline-induced cardiotoxicity. LVEF was better preserved in the experimental group than in the control group (weighted mean difference [WMD] −3.16%, 95% confidence interval [CI] [−5.78, −0.54], <i>p</i> = 0.02). Follow-up time, tumor type, drug type, and geographical region did not affect the results. There was no significant benefit of <i>E</i>/<i>A</i> in the experimental group (WMD 0.02, 95% CI [−0.06, 0.11], <i>p</i> = 0.58), and no increase in the incidence of hypotension (risk ratio 3.79, 95% CI [0.44, 32.89], <i>p</i> = 0.23). <b><i>Conclusions:</i></b> We found that prophylactic use of ACEI/ARB reduced the clinical or subclinical cardiotoxicity of anthracycline, and the increase in hypotensive events was not significant. Due to the relatively small number of clinical studies and participants, more related studies are necessary to further verify our results.