Endometrial liquid biopsy provides a consistent molecular miRNA roadmap of the secretory phase of the human endometrium

This NGS-based study describes the miRNA signature in human endometrial fluid during the secretory phase of natural and HRT cycles. A consistent endometrial miRNA signature was observed in the acquisition of endometrial receptivity. Interestingly, no significant differences in miRNA expression were found in natural vs. HRT cycles reinforcing the functional clinical similarities between both approaches.