RNA sequencing profile of cord blood endothelial progenitor cells

Endothelial colony forming cells (ECFC) are circulating endothelial progenitors that are recruited to sustain endothelial function, vascular growth and repair. They are particularly abundant in the perinatal period and can be isolated from umbilical cord blood, thus representing neonatal ECFC. In this study, we profiled neonatal ECFC depending on maternal metabolic derangements to investigate intrauterine epigenetic programming. Overall design: ECFC were isolated from umbilcal cord blood after pregnancies of lean, overweight and GDM (gestational diabetes mellitus) developing mothers with male and female neonates each.