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Chaudhury2020 - First order expansion model of CAR-T cell and tumour kinetics

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https://www.omicsdi.org/dataset/biomodels/MODEL2109110005
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This ordinary differential equation model of the cellular kinetics and pharmacodynamics of CAR-T cell therapy is described in the publication: Chaudhury, A., Zhu, X., Chu, L., Goliaei, A., June, C., Kearns, J. and Stein, A., 2020. Chimeric Antigen Receptor T Cell Therapies: A Review of Cellular Kinetic‐Pharmacodynamic Modeling Approaches. The Journal of Clinical Pharmacology, 60(S1). DOI: 10.1002/jcph.1691 Comment: This model is based on equations S1-S3 from the manuscript's supplemental information. A version of the approximated model, based on equations S4-S6, has been encoded separately. Curation Comment: There is a simulation error that has been attempted to be troubleshooted, however curation would be worth attempting again.
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2021-09-11
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