PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass.

<strong>Supplementary Table 6. CRISPR screen raw sgRNA counts.</strong> Excel sheet ‘Mellor et al Table S6_sgRNA_count.xlsx’. Output of the MAGeCK count command aligning Illumina sequencing reads to the sgRNA sequences within the Human Improved Genome-wide Knockout CRISPR library, following CRISPR/Cas9 screens in WT and <em>primpol</em> TK6 cells. <strong>Supplementary Table 7. CRISPR screen untreated summary.</strong> Excel sheet ‘Mellor et al Table S7_untreated_summary.xlsx’. Output of the MAGeCK test command comparing sgRNA abundance between the sequencing libraries produced following a CRISPR/Cas9 knockout screen in WT versus <em>primpol</em> TK6 cells in untreated conditions. <strong>Supplementary Table 8. CRISPR screen cisplatin treated summary.</strong> Excel sheet ‘Mellor et al Table S8_cddp_treated_summary.xlsx’. Output of the MAGeCK test command comparing sgRNA abundance between the sequencing libraries produced following a CRISPR/Cas9 knockout screen in WT versus <em>primpol</em> TK6 cells challenged with 7 days continuous 0.25 μM cisplatin treatment. <strong>readme.xlsx</strong> Tab 1: List of files Tab 2: Summary of CRISPR screen samples &amp; conditions