MM-GBSA calculations of the protein stability for the EGFR kinase^*.

*The columns 2–4 represent the protein stability contributions calculated for the Src/Cdk-like inactive form of EGFR for the WT, T790M and L858R mutants. The columns 5–7 represent the respective protein stability contributions calculated in the active form of EGFR for the WT, T790M and 858R mutants. All energies are in Kcal/mol. The contributions of the free energies are defined in the Materials and Methods section.