A Multiscale Analytical Surrogate Framework and Computational Protocol for Testing Electromagnetic Coupling to Follicular Redox and Stem-Cell-Niche Dynamics

Release Type: Pre-Execution Protocol and Analytical Surrogate Artifacts (v1.0.0) Package Archive: follicle_protocol_v1_0_0.zip This repository contains the version-controlled pre-execution computational protocol, parameter schemas, analytical surrogate datasets, and executable Python scripts for evaluating electromagnetic coupling to the melanocyte stem-cell (McSC) niche. The analytical surrogate scripts establish baseline physical feasibility constraints (1D attenuation bounds via Sobol sequence sampling, lumped Pennes thermal screening limits, nonlinear catalase redox sensitivity, and 1D Langevin restricted mean first-passage time). Explicit Scope Limitations To prevent premature therapeutic extrapolation, this protocol and its associated analytical surrogate data do not establish or claim: Therapeutic efficacy, visible repigmentation, or clinical outcomes for human canities. A safe human or consumer exposure regime. A verified nonthermal biological effect. A measured field-to-catalase coupling function. A measured electromagnetic or biological McSC bias. Package Contents Scripts/: Executable Python source code generating all figures and datasets (fig1_fig2_follicle_geometry.py, fig3_dielectric_uncertainty.py, fig4_thermal_dosimetry.py, fig5_redox_sensitivity.py, fig6_mcsc_dynamics.py, follicle_parameter_generator.py, follicle_zenodo_packager.py). Protocol Schematics & Figures: Publication-quality vector PDFs for Figures 1–6 (fig1_follicle_workflow.pdf, fig2_follicle_geometry.pdf, fig3_dielectric_uncertainty.pdf, fig4_thermal_dosimetry.pdf, fig5_redox_sensitivity.pdf, fig6_mcsc_dynamics.pdf). Analytical Surrogate Data: Numerical CSV datasets supporting the reported analyses (fig3_sobol_samples.csv, fig4_thermal_surrogate_data.csv, fig5_redox_sensitivity_data.csv, fig6_mcsc_survival_data.csv, follicle_redox_results.csv). Integrity Manifests: SHA256SUMS.csv and machine-readable metadata. Note: This release contains protocol-stage analytical surrogate data, parameter schemas, and workflow schematics only. It contains no completed high-fidelity 3D macroscopic FDTD (Meep) or bioheat (FEniCSx) production simulation results.