Comprehensive Single-Cell Chromatin and Transcriptomic Profiling of Peripheral Immune Cells in Non-Segmental Vitiligo

This study integrates single-cell RNA and ATAC sequencing to profile peripheral immune cells in nonsegmental vitiligo, providing insights into systemic immune dysregulation. We performed scRNA-seq and scATAC-seq on peripheral blood mononuclear cells (PBMCs) isolated by Ficoll-Paque density gradient centrifugation from vitiligo patients and healthy controls.