The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(3-(1H-tetrazol-5-yl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid

The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(3-(1H-tetrazol-5-yl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid Descriptor: 3-hydroxy-4-oxo-6-[3-(1H-tetrazol-5-yl)phenyl]-1,4-dihydropyridine-2-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein Authors: Morrison, C.N, Dick, B.L, Credille, C.V, Cohen, S.M. Deposit date: 2018-07-14 Release date: 2019-07-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.8 Å) Cite: SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease. J.Med.Chem., 62, 2019

甲型流感H1N1病毒PA核酸内切酶（PA Endonuclease）的N端结构域与6-(3-(1H-四唑-5-基)苯基)-3-羟基-4-氧代-1,4-二氢吡啶-2-羧酸形成的复合物
描述符：3-羟基-4-氧代-6-[3-(1H-四唑-5-基)苯基]-1,4-二氢吡啶-2-羧酸、二价锰离子（MANGANESE (II) ION）、聚合酶酸性蛋白（Polymerase acidic protein）
作者：Morrison, C.N.、Dick, B.L.、Credille, C.V.、Cohen, S.M.
沉积日期：2018-07-14
发布日期：2019-07-17
最后修改日期：2023-10-11
实验方法：X射线衍射（分辨率2.8埃）
引用文献：《流感病毒PA核酸内切酶强效结合抑制剂的构效关系探索》（SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease），《药物化学杂志》（J. Med. Chem.），第62卷，2019年