2-year Longitudinal Analyses of Peripheral Blood RNA in Huntington's Disease gene-positive and control subjects

Samples collected in the course of the TRACK HD study and used to analyse association between gene expression in blood and symptomatic progression of Huntington's disease Longitudinal analysis of UHDRS TMS versus gene expression in individual subjects followed by cross-sectional comparisons across phenotype groups at each timepoint Year 1: 24 Controls, 17 Huntington's mutation-positive presymptomatic far from age of predicted onset (Pre-A), 18 Huntington's mutation-positive presymptomatic near to age of predicted onset (Pre-B), 18 Manifest Huntington's disease Stage 1 (zHD1), 19 Manifest Huntington's disease Stage 2 (zHD2); Year 3: 20 Controls, 15 pre-A, 15 pre-B, 16 zHD1, 16 zHD 2 contributor: TRACK-HD Investigators