Confined Acid-Catalyzed Asymmetric Carbonyl–Ene Cyclization
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https://figshare.com/articles/dataset/Confined_Acid_Catalyzed_Asymmetric_Carbonyl_Ene_Cyclization/2119468
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资源简介：
A highly
enantioselective Brønsted acid catalyzed intramolecular
carbonyl–ene reaction of olefinic aldehydes has been developed.
Using a confined imidodiphosphate catalyst, the reaction delivers
diverse trans-3,4-disubstituted carbo- and heterocyclic
five-membered rings in high yields and with good to excellent diastereo-
and enantioselectivities. ESI-MS, NMR, and DFT mechanistic studies
reveal that the reaction proceeds via a stepwise pathway involving
a novel covalent intermediate.
创建时间：
2016-02-12
