Metabolomics dataset - Microbial metabolism of L-tyrosine protects against allergic inflammation

The constituents of the gut microbiome are determined by the local habitat, which itself is shaped by immunological pressures, such as mucosal IgA. Using a mouse model of restricted antibody repertoire, we identified a role for antibody-microbe interactions in shaping a community of bacteria with an enhanced capacity to metabolize L-tyrosine. This led to increased levels of p-cresol sulfate (PCS) that protected the host against allergic airway inflammation. PCS selectively reduced CCL20 production by airway epithelial cells, due to an uncoupling of EGFR and TLR4 signaling. Together, these data reveal a gut microbe-derived metabolite pathway that acts distally on the airway epithelium to reduce allergic airway responses, such as those underpinning asthma.