Crystal structure of EcThsA in complex with ADPR

Crystal structure of EcThsA in complex with ADPR Descriptor: Thoeris protein ThsA Macro domain-containing protein, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE Authors: Shi, Y, Masic, V, Mosaiab, T, Goulart, C.C, Hartley-Tassell, L, Sorbello, M, Vasquez, E, Mishra, B.P, Holt, S, Gu, W, Kobe, B, Ve, T. Deposit date: 2023-12-02 Release date: 2024-06-12 Last modified: 2024-07-10 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Structural characterization of macro domain-containing Thoeris antiphage defense systems. Sci Adv, 10, 2024与ADPR（腺苷二磷酸核糖，Adenosine Diphosphate Ribose）结合的EcThsA晶体结构。描述符：Thoeris蛋白ThsA，含宏结构域的蛋白质，配体为[(2R,3S,4R,5R)-5-(6-氨基嘌呤-9-基)-3,4-二羟基氧杂环戊烷-2-基]甲基[羟基-[[(2R,3S,4R,5S)-3,4,5-三羟基氧杂环戊烷-2-基]甲氧基]磷酰基]磷酸氢酯。作者：Shi, Y、Masic, V、Mosaiab, T、Goulart, C.C、Hartley-Tassell, L、Sorbello, M、Vasquez, E、Mishra, B.P、Holt, S、Gu, W、Kobe, B、Ve, T。提交日期：2023-12-02；发布日期：2024-06-12；最后修改日期：2024-07-10。实验方法：X射线衍射（分辨率2.14埃）。引用文献：《宏结构域含Thoeris抗噬菌体防御系统的结构表征》，《Science Advances》（Sci Adv），2024年，第10卷。